Talk:Acetazolamide

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Taste Effects Important enough to merit their own section

I don't have time right now to properly edit a new section, but use of acetazolamide to intentionally (as a MD prescription) or unintentionally alter taste is important enough for a separate section that might read something like:

Acetazolamide causes beer to taste bad because it inhibits carbonic anhydrase. This effect is not limited to beer but extends to all carbonated beverages.

Acetazolamide is a carbonic anhydrase inhibitor that interferes with the enzyme responsible for the rapid conversion of carbon dioxide and water into carbonic acid. When a person taking acetazolamide consumes a carbonated beverage, including beer, the inhibition of this enzyme leads to a higher concentration of carbonic acid in the mouth.

This increased carbonic acid concentration results in a taste disturbance, often described as bitter or "off". The effect is so well-known that it has been termed the "Champagne Blues" when referring to the altered taste of champagne while on acetazolamide.

Mountain climbers have reported that their "victory beer" on top of the mountain tastes flat when they've taken acetazolamide to counter altitude sickness. This occurs because the drug blocks the conversion of carbon dioxide to carbonic acid, dulling the beer's characteristic "bite".

The onset of this taste alteration is typically within 3 hours of taking acetazolamide, and it can persist for 6 to 7 hours in about half of the people who experience it. This effect is not limited to carbonated beverages; some individuals may also notice altered taste in non-carbonated foods and drinks.

Muñoz W, Lamm A, Poppers D, Lamm S. Acetazolamide promotes decreased consumption of carbonated drinks and weight loss. Oxf Med Case Reports. 2018 Oct 31;2018(11):omy081. doi: 10.1093/omcr/omy081. PMID: 30397500; PMCID: PMC6208055. Jaredroach (talk) 15:55, 1 March 2025 (UTC)[reply]